“The joy of discovery is certainly the liveliest that the mind of man can ever feel”

- Claude Bernard -

Original Research Articles

Polverino F, Santoriello C, De Sio V, Andò F, de Blasio F, Polverino M.Sexual intercourse and respiratory failure. Respir Med. 2008 Jun; 102(6):927-31. PMID: 18394872. 

D'Agostino B, Polverino M, Cirino G, Lombardi A, Grassi B, Sullo N, Santoriello C, Polverino F, Orlotti D, Matteis M, Ross F. Exercise capacity and cytochrome oxidase activity in muscle mitochondria of COPD patients. Respir Med. 2010 Jan; 104(1):83-90. PMID: 19716278. 

Cuomo G, Santoriello C, Polverino F, Ruocco L, Valentini G, Polverino M. Impaired exercise performance in systemic sclerosis and its clinical correlations. Scand J Rheumatol. 2010 Aug; 39(4):330-5. PMID: 20476863. 

Polverino F, Baraldo S, Bazzan E, Agostini S, Turato G, Lunardi F, Balestro E, Damin M, Papi A, Maestrelli P, Calabrese F, Saetta M. A novel insight into adaptive immunity in COPD: B cell activating factor belonging to the TNF family. Am J Respir Crit Care Med. 2010 Oct 15; 182(8):1011-9. PMID: 20581172.

Polverino M, Polverino F, Fasolino M, Andò F, Alfieri A, De Blasio F. Anatomy and neuro-pathophysiology of the cough reflex arc. Multidiscip Respir Med. 2012 June 18; 7(1):5. PMID: 2295836. 

Sullo N, Roviezzo F, Matteis M, Spaziano G, Del Gaudio S, Lombardi A, Lucattelli M, Polverino F, Lungarella G, Cirino G, Rossi F and D’Agostino B. Skeletal muscle oxidative metabolism  in an animal model of pulmonary emphysems: formoterol and skeletal muscle dysfunction. Am J Respir Cell Mol Biol. 2013 Feb; 48(2):198-203. PMID: 23144332.  

Polverino F, Polverino M, Santoriello C, Palladino R, Ricciardi M, Pistolesi M.  Voice box symptoms: a hitherto unknown presentation of pulmonary embolism. Am J Respir Crit Care Med. 2013 Jan 1;187(1):108-10. PMID: 23281354 

Knolle MD, Nakajima T, Hergrueter A, Gupta K, Polverino F, Craig VJ, Fyfe SE, Zahid M, Permaul P, Cernadas M, Montano G, Tesfaigzi Y, Sholl L, Kobzik L, Israel E, Owen CA. Adam8 limits the development of allergic airway inflammation in mice. J Immunol 2013 Jun 15; 190(12):6434-49. PMID: 23670189. PMCID: PMC3679335. 

Iannuzzi A, Licenziati MR, De Michele F, Verga MC, Santoriello C, Di Buono L, Renis M, Lembo L, Cappetta D, Polverino M, Polverino F. C-reactive-protein and carotid intima-media thickness in children with sleep-disordered breathing. J Clin Sleep Med. 2013 May 15; 9(5):493-8. PMID: 23674941. PMCID: PMC3629324. 

Craig, V, Polverino F, Laucho-Contreras M, Shi Y, Liu Y, Osorio J, Tesfaigzi Y, Rosas I, Owen CA. Mononuclear phagocytes and airway epithelial cells: novel sources of matrix metalloproteinase-8 (mmp-8) in patients with idiopathic pulmonary fibrosis. PLoS One. 2014 May 14; 9(5):e97485. PMID: 24828408. PMCID: PMC4020836. 

Roychaudhuri R, Hergrueter AH, Polverino F, Owen CA. ADAM9 is a novel product of polymorphonuclear neutrophils: subcellular localization, regulation of expression, and contributions to extracellular matrix protein degradation. J Immunol 2014 Sep 1; 193(5):2469-82. PMID:25063875


Cicchitto G, Musella V, Acitorio M, Capuano N, Fiorenzano G, Owen CA, Polverino M, Polverino F. Idiopathic pulmonary fibrosis and coronary artery disease. Multidiscip Respir Med. 2014 May 30; 9(1):31. PMID: 24976970. 


Matteis M*, Polverino F*, Spaziano G, Roviezzo F, Santoriello C, Sullo N, Bucci MR, Rossi F, Polverino M, Owen CA and D’Agostino B. Effects of sex hormones on bronchial reactivity during the menstrual cycle. BMC Pulm Med. 2014 Jul 1; 14(1):108. PMID: 24984749.    

Polverino F, Doyle-Eisele M, McDonald J, Kelly EM, Wilder J, Royer C, Laucho-Contreras M, Mauderly J, Divo M, Pinto-Plata V, Celli BR, Tesfaigzi Y, Owen CA. A novel non-human primate model of cigarette smoke-induced chronic obstructive pulmonary disease. Am J Pathol 2015 Mar; 185(3):741-55. PMID: 25542772. 

Laucho-Contreras M*, Polverino F*, Petersen H, Pinto-Plata V, Kelly E, Divo M, Sood A, Miller B, Taj-Singer R, Pilon A, Stripp B, Tesfaigzi Y, Celli B, Owen CA. Protective role for club cell secretory protein-16 (cc16) in the development of COPD. Eur Respir J. 2015 Jun; 45(6):1544-56. PMID: 25700379.  

Lao T, Glass K, Qiu W, Polverino F, Gupta K, Morrow J, Mancini JD, Vuong L, Perrella MA, Hersh CP, Owen CA, Quackenbush J, Yuan G, Silverman EK and Zhou X. Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring. Genome Med. 2015 Feb 14; 7(1):12. PMID: 25763110. 

Polverino F, Cosio BG, Pons J, Laucho-Contreras M, Tejera P, Iglesias A, Rios A, Jahn A, Sauleda J, Divo M, Pinto-Plata V, Scholl L, Rosas IO, Agusti A, Celli BR, Owen CA. B-cell activating factor: an orchestrator of lymphoid follicles in severe COPD. Am J Respir Crit Care Med. 2015 Jun 13; 192(6):695-705. PMID: 26073875. 

Cloonan SM, Glass K, Laucho-Contreras ME, Bhashyam AR, Cervo M, Pabón MA, Konrad C, Polverino F, Siempos II, Perez E, Mizumura K, Ghosh MC, Parameswaran H, Williams NC, Rooney KT, Chen ZH, Goldklang MP, Yuan GC, Moore SC, Demeo DL, Rouault TA, D'Armiento JM, Schon EA, Manfredi G, Quackenbush J, Mahmood A, Silverman EK, Owen CA, Choi AM. Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice. Nat Med. 2016 Feb; 22(2):163-74. PMID 26752519. 

Jiang Z, Lao T, Qiu W, Polverino F, Gupta K, Guo F, Mancini JD, Naing ZZ, Cho MH, Castaldi PJ, Sun Y, Yu J, Laucho-Contreras ME, Kobzik L, Raby BA, Choi AM, Perrella MA, Owen CA, Silverman EK, Zhou X. A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin. Am J Respir Crit Care Med. 2016 Jul 15;194(2):185-97PMID: 26862784.  

Polverino F, Laucho-Contreras M, Rojas Quintero J, Divo M, Pinto-Plata V, Sholl L, de-Torres JP, Celli BR, and Owen CA. Increased expression of a proliferation-inducing ligand (APRIL) in lung leukocytes and alveolar epithelial cells in COPD patients with non small cell lung cancer: A possible link between COPD and lung cancer? Multidiscip Respir Med 2016 Apr 4; 1:17. PMID: 27047662 

Schiavo A, Renis M, Polverino M, Iannuzzi A, Polverino F. Acid-base balance, serum electrolytes and need for non-invasive ventilation in patients with hypercapnic acute exacerbation of chronic obstructive pulmonary disease admitted to an internal medicine ward. Multidiscip Respir Med. 2016 May 25;11:23. PMID: 27226896.  

Polverino F, Laucho-Contreras M, Petersen H, Bijol V, Sholl LM, Choi M, Divo M, Pinto-Plata V, Tesfaigzi Y, Celli B, Owen CA. A Pilot Study Linking Endothelial Injury in Lungs and Kidneys in COPD. Am J Respir Crit Care Med. Jun 1;195(11):1464-1476. PMID: 28085500 

Cabrera López C, Casanova Macario C, Marín Trigo JM, de-Torres JP, Sicilia Torres R, González JM, Polverino F, Divo M, Pinto Plata V, Zulueta JJ, Celli B. Comparison of 2017 and 2015 Global Initiative for Obstructive Lung Disease: Impact on Grouping and Outcomes. Am J Respir Crit Care Med. 2017 Nov 3. PMID: 29099607 

Polverino F, de Torres JP, Santoriello C, Capuozzo A, Mauro I, Rojas J, D’Agostino B, Pistolesi M, Celli B, Polverino M, Owen CA. Gas Exchange and Breathing Pattern in Women with Postmenopausal Bone Fragility. Respiratory Medicine. 2018 Apr;137:141-146. PMID: 29605198 

Wang X*, Polverino F*, Rojas-Quintero J, Zhang D, Sánchez J, Yambayev I, Lindqvist E, Virtala R, Djukanovic R, Davies DE, Wilson S, O'Donnell R, Cunoosamy D, Hazon P, Higham A, Singh D, Olsson H, Owen CA. A Disintegrin and A Metalloproteinase-9 (ADAM9): A Novel Proteinase Culprit with Multifarious Contributions to COPD. Am J Respir Crit Care Med. 2018 Jun 4. PMID: 29864380 

Polverino F, Rojas-Quintero J, Wang X, Petersen H, Zhang L, Gai X, Higham A, Zhang D, Gupta K, Rout A, Yambayev I, Pinto-Plata V, Sholl LM, Cunoosamy D, Celli BR, Goldring J, Singh D, Tesfaigzi Y, Wedzicha J, Olsson H, Owen CA. A Disintegrin and A Metalloproteinase Domain-8 (ADAM8): A Novel Protective Proteinase in COPD. Am J Respir Crit Care Med. 2018 May 11. In press. PMID: 29750543 

Laucho-Contreras ME*, Polverino F,* Rojas-Quintero J, Wang X, Owen CA. Club cell protein 16 (Cc16) deficiency increases inflamm-aging in the lungs of mice. Physiol Rep. 2018 Aug;6(15):e13797. PMID:30084231 

De Benedetto F, Pastorelli R, Ferrario M, de Blasio F, Marinari S, Brunelli L, Wouters EFM,  Polverino F, Celli BR; Interdisciplinary Association for Research in Lung Disease (AIMAR) Study Group. Supplementation with Qter® and Creatine improves functional performance in COPD patients on long term oxygen therapy. Respir Med. 2018 Sep;142:86-93. PMID: 30170808 

Petersen H, Sood A,  Polverino F, Owen CA, Pinto-Plata V, Celli BR, Tesfaigzi Y. The Course of Lung Function in Middle-Aged Heavy Smokers: Incidence and Time to Early Onset of COPD. Am J Respir Crit Care Med. 2018 Aug 16. PMID: 30114375 

Pabón MA, Patino E, Bhatia D, Rojas-Quintero J, Ma KC, Finkelsztein EJ, Osorio JC, Malick F, Polverino F, Owen CA, Ryter SW, Choi AM, Cloonan SM, Choi ME. Beclin-1 regulates cigarette smoke-induced kidney injury in a murine model of chronic obstructive pulmonary disease. JCI Insight. 2018 Sep 20;3(18). PMID: 30232271


Tartaglione G, Spaziano G, Sgambato M, Russo TP, Liparulo A, Esposito R, Mirra S, Filosa R, Roviezzo F, Polverino F, D'Agostino B. Nociceptin/Orphanin Fq in inflammation and remodeling of the small airways in experimental model of airway hyperresponsiveness. Physiol Rep. 2018 Oct;6(20) PMID: 30370666


Casanova C, Marin JM, de Torres JP, Torres RS, Gonzales JM, Polverino F, Divo M, Pinot-Plata V, Zulueta J, Callejas FJ, Celli B. Arch Bronconeumol. 2019. Distribution and prognosis following the new risk stratification criteria of the Spanish COPD guidelines. Arch Bronconeumol. 2019 Feb. 


Polverino F, Lu B, Rojas J, Vargas SO, Patel A, Owen CA, Gerard NP, Gerard C, Cernadas M. CFTR regulates B cell activation and lymphoid follicle development. Respir Res. 2019;20(1):133. Published 2019 Jul 1. 


Sullivan JL, Bagevalu B, Glass C, Sholl LM, Kraft M, Martinez FD, Bastarrika G, de-Torres JP, Estepar RSJ, Guerra S, Polverino F†. B cell adaptive immune profile in emphysema-predominant COPD. Am J Respir Crit Care Med. 2019. Jul 26.


Esposito R, Spaziano G, Giannattasio D, Ferrigno F, Liparulo A, Rossi A, Roviezzo F,  Sessa M, Falciani M, Berrino L, Polverino M, Polverino F,  D'Agostino B. Montelukast improves symptoms and lung function in asthmatic women compared with men. Frontiers in Pharmacology 2019, Sep 24;10:1094.


Pinto-Plata V, Casanova C, Divo M, Tesfaigzi Y, Calhoun V, Sui J, Priolo C, Polverino F, Petersen H, de-Torres JP, Marin JM, Owen C, Baz R, Cordoba-Lanus E, Celli B. Plasma Metabolomics and survival differences in COPD patients. Resp. Res 2019. Oct 15;20(1):219.


Polverino F †, Hysinger EB, Gupta N, Willmering M, Olin T, Abman SH, Woods JC. Lung MRI as a potential complementary differential diagnostic tool for early COPD. Am J Med. 2020 Jun;133(6):757-760.


Kimura H, Francisco D, Conway M, Martinez FD, Vercelli D, Polverino F, Billheimer D, Kraft M.J Allergy Clin Immunol. 2020 May 15:S0091-6749(20)30647-3. Type 2 Inflammation Modulates ACE2 and TMPRSS2 in Airway Epithelial Cells. 


Polverino M, Capuozzo A, Cicchitto G, Ferrigno F, Mauro I, Santoriello C, Sirignano E, Aliverti A, Celli B, Polverino F†. Smoking Pattern in Men and Women: A Possible Contributor to Gender Differences in Smoke-related Lung Diseases. Am J Respir Crit Care Med. 2020 Jun 1. In press.


Cicchitto G, Capuozzo A, Cacace L, Cavallera A, Mauro I, Ferrigno F, Polverino F†. RP EBUS as a guide for transbronchial pulmonary biopsy in the diagnosis of Organizing Pneumonia. Multidisciplinary Respiratory Medicine 2020. In press.


 Reviews, Chapters, Monographs, and Editorials in Peer-Reviewed Journals  

Polverino M, Santoriello C, Polverino F, Polverino E, Musella V, Fiorenzano G, Ando’ F. Clinical, radiological and functional diagnosis. In: Di Cioccio L, Stazi G, editors. COPD in the elderly.  Rome: Casa Editrice Scientifica Internazionale; 2005. P. 9-33. 

Santoriello C, Cicchitto G, De Rosa C, Polverino F, Andò F, Polverino M. Drug resistant bronchial asthma. Multidiscip Respir Med 2006; 1:69-71. 

Cicchitto G, Fiorenzano G, Adiletta G, Panariello L, Giordano S, Polverino F, Polverino M. Familiar pulmonary alveolar microlitiasis. Multidiscip Respir Med 2006; 3:88-91. 

Polverino F, De Sio V, Santoriello C, Giannattasio D, Polverino M. Allergic cough: diagnostic-therapeutic mismatch. Multidiscip Respir Med 2006; 2:87-88. 


Polverino F, Polverino M. Management of elderly with respiratory failure. Geriatr Med J 2007; 1(1): 21-22. 

Polverino F, Santoriello C, De Sio V, Musella V, De Rosa C, Cicchitto G, De Blasio F, Andò F, Polverino M. Recumbent hypoxemia “clinodeoxia” in cirrhosis: relationship with age-related trends of alveolar ventilation and right-to-left shunting. Multidiscip Respir Med 2007; 1:28-36. 

Santoriello C, Polverino F, Fiorenzano G, Polverino M. Pulmonary artery agenesis: morphologic and functional assessment. Multidiscip Respir Med 2007; 1:115-117. 

Polverino F, Santoriello C, De Sio V, Giannattasio D, Di Buono L, Cicchitto G, De Rosa C, Andò F, Polverino M. Tests of upper air way obstruction (UAO) predicted values and application in patients with extrathoracic UAO. Multidiscip Respir Med 2007; 2:22-29. 

Polverino F, Cicchitto G, De Sio V, Di Buono L, Fiorenzano G, Giannattasio D, Musella V, Santoriello C, Viggiano D, Polverino M. Predictors of childhood asthma onset and role of early prophylaxis. Multidiscip Respir Med 2007; 3:12-18. 

Polverino F, Polverino E, Polverino G, Polverino S, Polverino M. Advanced stages of COPD can be lifelong asymptomatic: a lesson of life. Multidiscip Respir Med 2008; 3.228- 231. 

Santoriello C, Musella V, Polverino F, Polverino M. Signs of “myocardial ischemic equivalents” without ECG alterations, observed at cardiopulmonary exercise test. Multidiscip Respir Med 2008; 1:87-89. 

Polverino F, Cosio BG. Subphenotypes: the many faces of chronic obstructive pulmonary disease. Therapy 2009; 6(6):771–773. 

Polverino F, Longhini F, Vanaudenaerde B, Bikov A, Aamli A, Singanayagam A, Kahn N, Boots A, Skoczynski S. Juniors' voice at the ERS International Congress, Amsterdam 2015: Juniors' voice.﷟HYPERLINK "" Breathe (Sheff). 2015 Dec; 11(4):303-5. PMID: 27066124 

Laucho-Contreras ME, Polverino F, Tesfaigzi Y, Pilon A, Celli BR, Owen CA. Club Cell Protein 16 (CC16) Augmentation: A Potential Disease-modifying Approach for Chronic Obstructive Pulmonary Disease (COPD). Expert Opin Ther Targets. 2016 Feb; 11:1-15. PMID: 26781659 

Marin JM, Cote C, Casanova C, Pinto-Plata V, Montes de Oca M, Divo MJ, de Torres JP, Zulueta J, Cabrera C, Carrizo S, Polverino F, Celli BR; en representación del grupo BODE. Sumplifying the guidelines. The COPD 10 commandments. Arch Bronconeumol. 2016 Apr; 52(4):179-189. PMID: 26973024 

Polverino F, Seys LJ, Bracke KR, Owen CA. B cells in chronic obstructive pulmonary disease: moving to center stage. Am J Physiol Lung Cell Mol Physiol. 2016 Oct 1;311(4):L687-L695. PMID:27542809 

Polverino F, Celli BR, Owen CA. Reply to Cigarette Smoke is an Endothelial Cell Toxin. Am J Respir Crit Care Med. 2017 Jul 20. PMID: 28726486 

Polverino F, Celli BR, Owen CA. COPD: Breathing new life into old cardiovascular drugs? Annals of American Thoracic Society 2017. Sept 26. PMID: 28950067 


Polverino F, Celli BR, Owen CA. COPD as an endothelial disorder: endothelial injury linking lesions in the lungs and other organs? Pulm Circ. 2018 Jan-Mar;8(1):2045894018758528. PMID: 29468936 

Polverino F, Celli B. The Challenge of Controlling the COPD Epidemic: Unmet Needs. Am J Med. 2018 Sep;131(9S):1-6. Epub 2018 May 17. PMID:29778456 

Soriano JB, Polverino F, Cosio BG. What is Early COPD and Why is it Important? Eur Respir J. 2018 Oct 11. PMID: 30309976 

Polverino F. Deconvoluting COPD: Are B-cells the frontrunners? Am J Respir Crit Care Med. 2019 Jan 11. In press. 

Polverino F†, Sam A, Guerra S. COPD: to be or not to be. That is the question. Am. J Med. 2019. In press.


Polverino F†, Soriano J. Small Airways and Early Origins of COPD: Pathobiological and epidemiological considerations. Eur. Resp. J. 2020. In press. 


Scoppetta C, Di Gennaro G, Polverino F. Editorial - High Dose Intravenous Immunoglobulins as a Therapeutic Option for COVID-19 Patients. Eur Rev Med Pharmacol Sci. 2020 May;24(9):5178-5179. 


Polverino F†. Cigarette Smoking and COVID-19: A Complex Interaction. Am J Respir Crit Care Med. 2020 Jun 12. In press


Polverino F† and Curtis JL. The ABCs of granulomatous lung diseases: age-associated B cells. Am J Respir Crit Care Med. 2020. In press


Polverino F†, Balestro E, Spagnolo P. Clinical presentations, pathogenesis, and therapy of sarcoidosis: state of the art. Journal of Clinical Medicine 2020. In press.